Hydrochloric Acid → 1-Methoxycarbonyl-3-(2-aminophenyl)thiourea hydrochloride
反応式
[ClH:1].[CH3:2][O:3][C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH2:16])=[S:8])=[O:5]>O1CCOCC1>[ClH:1].[CH3:2][O:3][C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH2:16])=[S:8])=[O:5]参加物
4
反応条件
- 温度
- 25 °C
実験手順
Concentrated hydrochloric acid (3 ml) was added dropwise to a stirred suspension of 1-methoxycarbonyl-3-(2-aminophenyl)thiourea in dry dioxan (75 ml), the temperature of the reaction mixture being maintained at 20°-25° C. during the addition by slight external cooling. The clear solution obtained was stirred for a further 30 minutes at 25° C. during which time a solid separated. This was filtered off, washed with acetone and recrystallised from ethanol to give 1-methoxycarbonyl-3-(2-aminophenyl)thiourea hydrochloride (5.1 g), m.p. 176°-178° C. (with decomposition).