Dimethylamine → N-(2-nitrophenyl)-2-dimethylaminoacetamide

HRID 1415634ノート

反応式

HRID 1415634 の反応式
[CH3:1][NH:2][CH3:3].[N+:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH:13][C:14](=[O:17])[CH2:15]Cl)([O-:6])=[O:5]>C(O)C>[N+:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH:13][C:14](=[O:17])[CH2:15][N:2]([CH3:3])[CH3:1])([O-:6])=[O:5]

参加物

4

反応物 2

HCID 674DimethylamineHCID 2224432-chloro-N-(2-nitrophenyl)acetamide

生成物 1

HCID 2958870N-(2-nitrophenyl)-2-dimethylaminoacetamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution of dimethylamine in ethanol (40 ml. of a 33% w/w solution) was added to a suspension of N-(2-nitrophenyl)-2-chloroacetamide (14.9 g) [prepared by the method described by G. Tennant, J.C.S., (1963), 2428] in ethanol (70 ml) and the mixture was heated to reflux, with stirring, for 2hours. After cooling, the ethanol and excess dimethylamine were evaporated off under reduced pressure and the solid residue was treated with an aqueous potassium hydroxide solution (100 ml., 40% w/v). The resulting suspension was extracted with diethyl ether (3 × 100 ml) and the combined extracts dried over magnesium sulphate and evaporated to give N-(2-nitrophenyl)-2-dimethylaminoacetamide (13.8 g), m.p. 44°-47° C., sufficiently pure to be used in the next stage of the synthesis, the preparation of N-(2-aminophenyl)-2-dimethylaminoacetamide.

後処理

  1. customprepared by the method
  2. temperatureto reflux
  3. temperatureAfter cooling
  4. customthe ethanol and excess dimethylamine were evaporated off under reduced pressure
  5. additionthe solid residue was treated with an aqueous potassium hydroxide solution (100 ml., 40% w/v)
  6. extractionThe resulting suspension was extracted with diethyl ether (3 × 100 ml)
  7. dry with materialthe combined extracts dried over magnesium sulphate
  8. customevaporated

出典と根拠

ORDレコード
ord-302f9863ddcd4d049d931e62a93e2b9d
出典データセット
uspto-grants-1977_01
特許番号
US04005217

反応ノート

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