N-(2-nitrophenyl)-2-dimethylaminoacetamide → N-(2-aminophenyl)-2-(dimethylamino)acetamide

HRID 1415635ノート

反応式

HRID 1415635 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:16])[CH2:12][N:13]([CH3:15])[CH3:14])([O-])=O.[H][H]>[Pt]=O.C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:16])[CH2:12][N:13]([CH3:14])[CH3:15]

参加物

5

反応物 2

HCID 2958870N-(2-nitrophenyl)-2-dimethylaminoacetamideHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 16784338N-(2-aminophenyl)-2-(dimethylamino)acetamide収率 77.8%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

N-(2-nitrophenyl)-2-dimethylaminoacetamide (13.8 g), platinum oxide (0.2 g) and ethanol (100 ml) were mixed together and shaken in an atmosphere of hydrogen at atmospheric pressure and laboratory temperature until absorption of hydrogen ceased (4.5 litres of hydrogen were absorbed in 2hours). The mixture was then filtered and the ethanol evaporated off under reduced pressure. The solid residue so obtained was recrystallised from cyclohexane to give N-(2-aminophenyl)-2-dimethylaminoacetamide (9.3 g), m.p. 121°-123° C.

後処理

  1. custom(4.5 litres of hydrogen were absorbed in 2hours)
  2. filtrationThe mixture was then filtered
  3. customthe ethanol evaporated off under reduced pressure
  4. customThe solid residue so obtained
  5. customwas recrystallised from cyclohexane

出典と根拠

ORDレコード
ord-3c74c1875df44f629e9d42366603f025
出典データセット
uspto-grants-1977_01
特許番号
US04005217

反応ノート

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