M-Cresol → Cresentyl

HRID 1415889ノート

反応式

HRID 1415889 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:10]1[C:15]([OH:16])=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17].C(N(CC)CC)C>CCOCC>[C:1]([O:16][C:15]1[CH:14]=[CH:13][CH:12]=[C:11]([CH3:17])[CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 342M-CresolHCID 7412Benzoyl chlorideHCID 8471Triethylamine

生成物 1

HCID 69193Cresentyl収率 212%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of benzoyl chloride (32.5 g, Aldrich) in ether (200 ml) was added dropwise to a stirred solution of m-cresol (25.0 g, Aldrich) and triethylamine (27.2 g, Aldrich) in ether (500 ml). The reaction mixture was stirred at room temperature for 1 hour then filtered. The ethereal filtrate was washed with saturated NaHCO3 and water then dried over Na2SO4. The ether layer was separated, dried and concentrated in vacuo to give the desired product (104.0 g) as a white solid, mp 45-47C. 1H NMR consistent with the desired structure.

後処理

  1. filtrationthen filtered
  2. washThe ethereal filtrate was washed with saturated NaHCO3 and water
  3. dry with materialthen dried over Na2SO4
  4. customThe ether layer was separated
  5. customdried
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8232430216cf41ae9ef7c1d6c1f2ebf5
出典データセット
uspto-grants-1999_06
特許番号
US05910494

反応ノート

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