Benzyl Chloride → 2-Benzyloxy-6-chlorotoluene

HRID 1416077ノート

反応式

HRID 1416077 の反応式
[Cl:1][C:2]1[C:3]([CH3:9])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH2:10](Cl)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[CH2:10]([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[CH3:9])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 7503Benzyl ChlorideHCID 11430Potassium Carbonate2 回HCID 148563-Chloro-o-cresol

生成物 1

HCID 117465342-Benzyloxy-6-chlorotoluene収率 88.3%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 143 g (1.0 mol) of 3-chloro-2-methylphenol, 139 g (1.1 mol) of benzyl chloride, 276 g (2.0 mol) of potassium carbonate and 680 g of methyl ethyl ketone (MEK) is heated under reflux with stirring. After 8 hours, a further 25 g (0.18 mol) of potassium carbonate are added and the mixture is then heated under reflux for a further 8 hours. The batch is filtered and the filter cake is washed with MEK. After working up by distillation, 206 g of 2-benzyloxy-6-chlorotoluene (b.p. 161 ° C., 3 mbar) are obtained as a pale yellow liquid in 99.6% purity (surface area % according to GC). This corresponds to a yield of 88.3% of theory.

後処理

  1. temperatureis heated
  2. temperatureunder reflux
  3. temperaturethe mixture is then heated
  4. temperatureunder reflux for a further 8 hours
  5. filtrationThe batch is filtered
  6. washthe filter cake is washed with MEK
  7. distillationAfter working up by distillation, 206 g of 2-benzyloxy-6-chlorotoluene (b.p. 161 ° C., 3 mbar)
  8. customare obtained as a pale yellow liquid in 99.6% purity (surface area % according to GC)

出典と根拠

ORDレコード
ord-fedab3ab2c1942d7bfcf8c467207f665
出典データセット
uspto-grants-1999_06
特許番号
US05910605

反応ノート

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