Triethylamine → 3,3-Dimethylbutyl methanesulfonate
反応式
[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH2:4][OH:5].C(N(CC)CC)C.[CH3:15][S:16](Cl)(=[O:18])=[O:17]>ClCCl>[CH3:15][S:16]([O:5][CH2:4][CH2:3][C:2]([CH3:7])([CH3:6])[CH3:1])(=[O:18])=[O:17]参加物
5
実験手順
To a stirred solution of 3,3-dimethyl-1-butanol (2 ml) in dichloromethane (48 ml), under nitrogen, was added triethylamine (4.64 ml) and the resulting solution cooled to 0/C. Methanesulphonylchloride (1.28 ml) was then added dropwise via syringe and stirring continued for 18 h as the reaction warmed to room temperature. The reaction was then concentrated onto silica and purified by flash chromatography to give the title compound as a yellow oil.
後処理
- temperaturethe resulting solution cooled to 0/C
- concentrationThe reaction was then concentrated onto silica
- custompurified by flash chromatography
出典と根拠
- ORDレコード
- ord-e27acd651a474426b355d3f6d72b6602
- 出典データセット
- uspto-grants-1999_06
- 特許番号
- US05912252
反応ノート
読み込み中…