4-Bromophenol → p-Bromophenyl propionate

HRID 1416174

反応式

HRID 1416174 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:16](Cl)(=[O:19])[CH2:17][CH3:18]>CN(C)C1C=CN=CC=1.ClCCl>[C:16]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:19])[CH2:17][CH3:18]

参加物

6

反応物 3

HCID 78084-BromophenolHCID 8471TriethylamineHCID 62324Propionyl chloride

生成物 1

HCID 90205p-Bromophenyl propionate

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

4-Bromophenol (259 g) and 4-dimethylaminopyridine (1.5 g) were dissolved in dichloromethane (1000 ml), the solution was cooled in an ice bath and triethylamine (219 ml) was added portionwise such that the reaction temperature was kept below 20° C. Propionyl chloride (137 ml) was then added over 1 hour and the resulting mixture was stirred at room temperature for 2 hours. The mixture was washed with water followed by brine, then dried (anhydrous magnesium sulphate) and the solvent removed under reduced pressure to yield 4-bromophenyl propionate (344 g) as a green oil.

後処理

  1. temperaturethe solution was cooled in an ice bath
  2. customwas kept below 20° C
  3. washThe mixture was washed with water
  4. dry with materialdried (anhydrous magnesium sulphate)
  5. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-e23305ecedd6434f86a9cdf31e6750fb
出典データセット
uspto-grants-1999_06
特許番号
US05912244

関連ノート

読み込み中…