Hydrochloric Acid → 1-(5-Bromo-2-hydroxyphenyl)propan-1-one

HRID 1416175

反応式

HRID 1416175 の反応式
C([O:5][C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1)(=O)CC.[Cl-].[Al+3].[Cl-].[Cl-].Cl>>[Br:12][C:9]1[CH:10]=[CH:11][C:6]([OH:5])=[C:7]([C:6](=[O:5])[CH2:7][CH3:8])[CH:8]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 90205p-Bromophenyl propionateHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 7364091-(5-Bromo-2-hydroxyphenyl)propan-1-one収率 191.3%

実験手順

4-Bromophenyl propionate (115 g) (see Preparation 1) and aluminium chloride (150 g) were heated together at approximately 90° C. for 15 minutes. The solution became dark and hydrogen chloride gas was evolved. After cooling the black mass was carefully added to ice and a brown solid formed. The mixture was extracted with dichloromethane. The organic extract was separated, washed with brine, dried (anhydrous magnesium sulphate) and the solvent removed under reduced pressure to yield 1-(5-bromo-2-hydroxyphenyl)propan-1-one (110 g) as a yellow solid.

後処理

  1. temperatureAfter cooling the black mass
  2. additionwas carefully added to ice
  3. customa brown solid formed
  4. extractionThe mixture was extracted with dichloromethane
  5. extractionThe organic extract
  6. customwas separated
  7. washwashed with brine
  8. dry with materialdried (anhydrous magnesium sulphate)
  9. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-c479031725ce44fd971084f50ff4647f
出典データセット
uspto-grants-1999_06
特許番号
US05912244

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