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Triethylamine → 6-Bromo-2-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-imidazo[1,2-a]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-(4-Fluorophenyl)piperazine | HCID 75260 | — |
| 反応物 | 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine | HCID 11622894 | — |
| 溶媒 | Ethylene Glycol | HCID 174 | — |
| 生成物 | 6-Bromo-2-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-imidazo[1,2-a]pyridine | HCID 19367097 | 62.1% |
反応手順
Following the general procedure of Example 11 and making noncritical variations, 6-bromo-2-(chloromethyl)imidazo[1,2-a]pyridine (0.253 g), 1-(4-fluorophenyl)piperazine (Aldrich; 0.186 g), triethylamine (Aldrich; 0.104 g), and ethylene glycol (2 mL) give 0.249 g of the title compound after chromatography (silica gel, methanol/dichloromethane, 4/96) and crystallization from dichloromethane/hexane; mp 110-112° C.; MS m/z 388, 390; IR (mineral oil) 1511, 1234, 1219, 1448, 1326 cm-1. 1H NMR (CDCl3) δ2.74, 3.16, 3.77, 6.87-6.98, 7.21, 7.48, 7.53, 8.24.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05912246 |
| 出典データセット | uspto-grants-1999_06 |
| ORD ID | ord-77f1ba69e3964e479869ac3bde5e2e55 |
| 出典メモ | uspto-grants-1999_06 |