Acetone → HCID 67582065、化合物
反応式
[OH:1][C@@H:2]1[CH2:6][O:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:9]=1.CC(C)=[O:26]>>[C:6]([OH:26])(=[O:5])[CH3:2].[OH:1][C@@H:2]1[CH2:6][O:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[N:9]=1参加物
3
実験手順
4-[trans-(4-Hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 11) (200 mg) is dissolved in acetone (20 ml) with heating, and the solution is filtered, and the filtrate is concentrated and thereto is added acetic acid (50 mg), and the mixture is allowed to stand at room temperature. The precipitated crystals are separated by filtration to give 4-[trans-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (171 mg).
後処理
- temperaturewith heating
- filtrationthe solution is filtered
- concentrationthe filtrate is concentrated
- additionis added acetic acid (50 mg)
- customto stand at room temperature
- customThe precipitated crystals are separated by filtration