Hydrochloride methanol → HCID 67582048、化合物
反応式
[OH:1][C@@H:2]([C@H:21]([OH:23])[CH3:22])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1.[ClH:24].CO>CO>[ClH:24].[OH:1][C@@H:2]([C@H:21]([OH:23])[CH3:22])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[N:6]=1参加物
4
実験手順
4-[(2R,3R)-(2,3-Dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 55) (0.85 g) is dissolved in methanol (10 ml), and thereto is added 2N HCl-methanol (1.6 ml), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is recrystallized from ethanol to give 4-[(2R,3R)-(2,3-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (0.3 g).
後処理
- customthe mixture is evaporated to dryness under reduced pressure