Hydrochloride methanol → HCID 67581967、化合物
反応式
[OH:1][C@@H:2]([CH2:22][OH:23])[CH2:3][CH2:4][O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[N:7]=1.[ClH:24].CO>CO>[ClH:24].[OH:1][C@@H:2]([CH2:22][OH:23])[CH2:3][CH2:4][O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([N:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[N:7]=1参加物
4
実験手順
To a solution of 4-[(3R)-(3,4-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 59) (1.90 g) in methanol (38 ml) is added 2N HCl-methanol (3.59 ml), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is washed with acetone and recrystallized from methanol-acetone to give 4-[(3R)-(3,4-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (1.61 g) as crystals.
後処理
- custom