Hydrochloride methanol → HCID 67583545、化合物

HRID 1416507ノート

反応式

HRID 1416507 の反応式
[OH:1][C@@H:2]([C@H:21]([OH:24])[CH2:22][OH:23])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1.[ClH:25].CO>CO>[ClH:25].[OH:1][C@@H:2]([C@H:21]([OH:24])[CH2:22][OH:23])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1

参加物

4

反応物 2

HCID 21893726Hydrochloride methanolHCID 54235254HCID 54235254、化合物

生成物 1

HCID 67583545HCID 67583545、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-[(2R,3R)-(2,3,4-Trihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf Example 64) (0.5 g) is dissolved in methanol (40 ml), and thereto is added 2N HCl-methanol (0.82 ml), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is recrystallized from ethanol to give 4-[(2R,3R)-(2,3,4-trihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (0.14 g).

後処理

  1. customthe mixture is evaporated to dryness under reduced pressure
  2. customThe resulting residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-06f34af567b245959df6c6b0b9bbff79
出典データセット
uspto-grants-1999_06
特許番号
US05912247

反応ノート

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