(S)-(-)-N-Boc-prolinol → 2-methyl-3-(2-pyrrolidinylmethoxy)pyridine dihydrochloride, (R)-

反応式

C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13][OH:14])=O)(C)(C)C.[Cl:15]C1C=C(OC[C@@H]2CCCN2C(OC(C)(C)C)=O)C=NC=1.C(O[C:41]([N:43]1[CH2:47][CH2:46][CH2:45][C@H:44]1[CH2:48]O)=O)(C)(C)C>>[ClH:15].[ClH:15].[CH3:48][C:44]1[C:45]([O:14][CH2:13][C@H:9]2[CH2:10][CH2:11][CH2:12][NH:8]2)=[CH:46][CH:47]=[CH:41][N:43]=1

参加物

反応物 3

HCID 643448(S)-(-)-N-Boc-prolinol

HCID 688279N-(tert-Butoxycarbonyl)-D-prolinol

HCID 542993835-chloro-3-((1-t-butoxycarbonyl-2-(S)-pyrrolidinyl)methoxy)pyridine

生成物 1

HCID 702036652-methyl-3-(2-pyrrolidinylmethoxy)pyridine dihydrochloride, (R)-

実験手順

Replacing (S)-1-t-butoxycarbonyl-2-pyrrolidinemethanol of Example 15 with (R)-1-t-butoxycarbonyl-2-pyrrolidinemethanol (Aldrich Chemical Co.), and following the procedure of steps 15a and 15b, the title compound was prepared. The MS and 1H NMR spectra were similar to compound 15a.

出典と根拠

ORDレコード: ord-d56679b16d064fd0bbf48c82654bc6b0
出典データセット: uspto-grants-1999_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05914328

反応ノート

読み込み中…

参加物