Ethylenediamine → 7-[N'-(2-aminoethyl)thioureido]-5-cyano-8-methylquinoline

HRID 1416903ノート

反応式

HRID 1416903 の反応式
[C:1]([C:3]1[CH:12]=[C:11]([N:13]=[C:14]=[S:15])[C:10]([CH3:16])=[C:9]2[C:4]=1[CH:5]=[CH:6][CH:7]=[N:8]2)#[N:2].[CH2:17]([NH2:20])[CH2:18][NH2:19]>C1(C)C=CC=CC=1>[NH2:19][CH2:18][CH2:17][NH:20][C:14](=[S:15])[NH:13][C:11]1[C:10]([CH3:16])=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[N:8]2)=[C:3]([C:1]#[N:2])[CH:12]=1

参加物

4

反応物 2

HCID 3301EthylenediamineHCID 184653735-Cyano-7-isothiocyanato-8-methylquinoline

生成物 1

HCID 184653747-[N'-(2-aminoethyl)thioureido]-5-cyano-8-methylquinoline

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

A solution of 5-cyano-7-isothiocyanato-8-methylquinoline (0.85 g) in toluene (100 mL) is added dropwise to a solution of ethylenediamine (1.94 g) in toluene (100 mL). A yellow-white precipitate is observed after the reaction stirs at room temperature for 10 minutes. The precipitate is filtered and dried in vacuo to afford 7-[N'-(2-aminoethyl)thioureido]-5-cyano-8-methylquinoline as a yellow-white solid.

後処理

  1. filtrationThe precipitate is filtered
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-c3dfa875a4024f4bb3d08b7c9227aa51
出典データセット
uspto-grants-1999_06
特許番号
US05916900

反応ノート

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