Ethylenediamine → HCID 19701537、化合物
反応式
[F:1][C:2]1[CH:11]=[C:10]([N:12]=[C:13]=[S:14])[C:9]([CH3:15])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[CH2:16]([NH2:19])[CH2:17][NH2:18]>C1(C)C=CC=CC=1>[NH2:18][CH2:17][CH2:16][NH:19][C:13](=[S:14])[NH:12][C:10]1[C:9]([CH3:15])=[C:8]2[C:3]([CH:4]=[CH:5][CH:6]=[N:7]2)=[C:2]([F:1])[CH:11]=1参加物
4
実験手順
A solution of 5-fluoro-7-isothiocyanato-8-methylquinoline (0.38 g) in toluene (40 mL) is added dropwise to a solution of ethylenediamine (0.78 g) in toluene (40 mL). A white precipitate is observed after the reaction stirs for 10 minutes at room temperature. The precipitate is filtered and dried in vacuo to afford 7-[N'-(2-aminoethyl)thioureido]-5-fluoro-8-methylquinoline as a white solid.
後処理
- filtrationThe precipitate is filtered
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-42dca31e0136423f824375db40849fb0
- 出典データセット
- uspto-grants-1999_06
- 特許番号
- US05916900
反応ノート
読み込み中…