化工社化工社 化学情報印刷レポート · 研究参考用
8-Cyano-octanoic acid → 9-Aminononanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 8-Cyano-octanoic acid | HCID 11084300 | — |
| 触媒 | Cobalt | HCID 104730 | — |
| 溶媒 | Ammonia | HCID 222 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 9-Aminononanoic acid | HCID 136877 | 92.5% |
反応手順
84.5 g of 8-cyanooctanoic acid dissolved in 500 ml of isopropyl alcohol saturated with NH3 are hydrogenated at 50° C. and 80 bar for 3 hours, using 20 g of cobalt-Raney as catalyst. The catalyst is filtered out and the solution is concentrated. Cooling and purification produce 9-aminononanoic acid (80 g) in the form of a crystalline solid product with a m.p. of 190-192° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05917067 |
| 出典データセット | uspto-grants-1999_06 |
| ORD ID | ord-1b028e65be614122ad30c0bf9ba1a2f2 |
| 出典メモ | uspto-grants-1999_06 |