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Methanol → Methyl 3-cyclohexyl-D-alaninate--hydrogen chloride (1/1)
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (R)-2-Amino-3-cyclohexylpropanoic acid hydrochloride | HCID 56777007 | — |
| 生成物 | Methyl 3-cyclohexyl-D-alaninate--hydrogen chloride (1/1) | HCID 56777179 | 95.8% |
反応手順
To cold (-20° C.) and dry methanol (195 ml) was added dropwise thionylchloride (28 ml). H-D-ChaOH.HCl (40 g) was added and the reaction mixture was heated under reflux for 5 h. The mixture was concentrated in vacuo and coevaporated with methanol (3 times). The residue was crystallized from methanol/diethylether yielding H-D-Cha-OMe.HCl as a white crystalline powder (40.9 g, 95.8%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05877156 |
| 出典データセット | uspto-grants-1999_03 |
| ORD ID | ord-8746ba7d899047db9e48974f2f3fec94 |
| 出典メモ | uspto-grants-1999_03 |