Hydrazine → HCID 54501591、化合物

HRID 1417315ノート

反応式

HRID 1417315 の反応式
[N:1]1([C:6]2[CH:27]=[CH:26][C:9]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3C(=O)C4C(=CC=CC=4)C3=O)=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1.NN>C(O)C>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][NH2:15])=[CH:26][CH:27]=2)[CH:5]=[N:4][N:3]=[N:2]1

参加物

4

反応物 2

HCID 9321HydrazineHCID 67598186HCID 67598186、化合物

生成物 1

HCID 54501591HCID 54501591、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A suspension of 19.4 g of 2-[4-[4-(1H-tetrazol-1-yl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione (Example 38) in 400 ml boiling ethanol is treated with 3 ml of anhydrous hydrazine, and the mixture stirred at reflux for 16 hours. The precipitate is collected, washed with 200 ml of hot 1.5N HCl, and 50 ml of H2O. The combined ethanol, hydrochloric acid, and water filtrates are taken to dryness in vacuo to give the hydrochloride salt of the title compound. A portion of the salt was recrystallized from hot ethanol, m.p. 197°-198° C. (dec.).

後処理

  1. temperatureat reflux for 16 hours
  2. customThe precipitate is collected
  3. washwashed with 200 ml of hot 1.5N HCl, and 50 ml of H2O

出典と根拠

ORDレコード
ord-be7bda1fb04847e8bc6a9ba5b9f71bbd
出典データセット
uspto-grants-1999_03
特許番号
US05877196

反応ノート

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