関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dipropylamine | HCID 8902 | — |
| 反応物 | 2-Chloro-4-cyanopyridine | HCID 568638 | — |
| 生成物 | 2-(Dipropylamino)isonicotinonitrile | HCID 14640854 | — |
反応手順
2-Chloroisonicotinonitrile (1.0 g) and dipropylamine (10 mL) were placed in a sealed heavy wall tube and heated to 100° C. for 18 h. The mixture was removed from heat and cooled to room temperature. The dipropylamine was removed under reduced pressure and the residue chromatographed on silica gel using 2% ethyl acetate in hexanes as eluent to give 1.06 g of the title compound: MS (ESI+) for C12H17N3 m/z 204.1 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07727997B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-8806db662bf2457fa8f1fc0dac0d23e5 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
