Hydrochloric Acid → 8-Amino-octanoic acid methyl-butyl-amide

HRID 1417420ノート

反応式

HRID 1417420 の反応式
[CH3:1][N:2]([CH2:20][CH2:21][CH2:22][CH3:23])[C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11]C(OC(C)(C)C)=O.Cl>O1CCOCC1>[CH3:1][N:2]([CH2:20][CH2:21][CH2:22][CH3:23])[C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH2:11]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 537219698-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide

生成物 1

HCID 541906878-Amino-octanoic acid methyl-butyl-amide

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Combine 8-(t-butoxycarbonyl)amino-octanoic acid methyl-butyl-amide and 4M hydrochloric acid in dioxane (10 mL). After 1 hour, the reaction mixture is evaporated to a residue. Partition the residue between toluene and 1M sodium hydroxide solution. Extract the aqueous layer with toluene. Combine the organic layers, dry over MgSO4, and filter to give the title compound as a toluene solution. Evaporate in vacuo to give the title compound.

後処理

  1. customthe reaction mixture is evaporated to a residue
  2. customPartition the residue between toluene and 1M sodium hydroxide solution
  3. extractionExtract the aqueous layer with toluene
  4. dry with materialdry over MgSO4
  5. filtrationfilter

出典と根拠

ORDレコード
ord-1fb774483c154405bca8f0fa6a4001ad
出典データセット
uspto-grants-1999_03
特許番号
US05877202

反応ノート

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