4-(Piperazin-1-yl)benzene-1-sulfonamide → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]-cis-3,5-dimethylpiperazin-1-yl]benzamide

HRID 1417852

反応式

HRID 1417852 の反応式
[CH:1]1([CH2:11][C:12](O)=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][O:2]1.[CH3:15][CH:16]1[NH:21][CH:20]([CH3:22])[CH2:19][N:18]([C:23]2[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=2)[CH2:17]1.N1(C2C=CC(S(N)(=O)=O)=CC=2)CCNCC1.ClCCC1C2C(=CC=CC=2)C(C)CO1.C[C@H]1CNC[C@@H](C)N1>>[C@H:1]1([CH2:11][CH2:12][N:21]2[C@@H:16]([CH3:15])[CH2:17][N:18]([C:23]3[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=3)[CH2:19][C@H:20]2[CH3:22])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][O:2]1

参加物

6

反応物 5

HCID 9018974-(Piperazin-1-yl)benzene-1-sulfonamideHCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 133088642-(3,4-dihydro-1H-2-benzopyran-1-yl)acetic acidHCID 232889214-(3,5-Dimethylpiperazin-1-yl)benzamideHCID 232889381-(2-Chloroethyl)-4-methyl-isochroman

生成物 1

HCID 15487843(S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]-cis-3,5-dimethylpiperazin-1-yl]benzamide

実験手順

Following the general procedure of EXAMPLE 48 and making non-critical variations (-)-isochromanylacetic acid (LXI, EXAMPLE 45, 0.346 g) and 4-(3,5-dimethylpiperazin-1-yl)benzamide [(IV), 0.462 g; prepared from 4-fluorobenzamide (III) and cis-2,6-dimethylpiperazine (II, Aldrich) by the procedure of EXAMPLE 47, Step 1] gives the title compound, mp 206°-207°; MS (m/z) 393; IR (mineral oil) 1640, 1607, 1246, 3383, 1402, 1395, 1422, 1112 and 1332 cm-1.

出典と根拠

ORDレコード
ord-2f643efe2821488f83ca49dfa690eff7
出典データセット
uspto-grants-1999_03
特許番号
US05877317

関連ノート

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