Hydrochloric Acid → N-[2-t-butyl-5-(aminomethyl)phenyl]-3-(2,4-dimethoxyphenyl)octanamide hydrochloride

HRID 1418189ノート

反応式

HRID 1418189 の反応式
[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][C:7]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:5])([CH3:4])[CH3:3]>O1CCOCC1.C(OCC)C>[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][C:7]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:3])([CH3:4])[CH3:5]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 19348478HCID 19348478、化合物

生成物 1

HCID 19348562N-[2-t-butyl-5-(aminomethyl)phenyl]-3-(2,4-dimethoxyphenyl)octanamide hydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 312751,4-Dioxane溶媒

実験手順

A 4N solution of hydrogen chloride in dioxane was added to a solution of N-[2-t-butyl-5-(aminomethyl)phenyl]-3-(2,4-dimethoxyphenyl)octanamide (prepared as described in Preparation 26A) in diethyl ether, and the precipitate which separated out was collected by filtration and washed with hexane to give the desired hydrochloride, melting at 102°-106° C.

後処理

  1. customthe precipitate which separated out
  2. filtrationwas collected by filtration
  3. washwashed with hexane

出典と根拠

ORDレコード
ord-bf3bf3f32ca040d7a2142ed252ab3f47
出典データセット
uspto-grants-1999_03
特許番号
US05880147

反応ノート

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