3-Methoxypropyl 4-methylbenzenesulfonate → 3-[4-(3-Methoxypropoxy)-2-methoxyphenyl]heptanoic Acid

HRID 1418219ノート

反応式

HRID 1418219 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([O:12]C)=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1.[CH3:20][O:21][CH2:22][CH2:23][CH2:24]OS(C1C=CC(C)=CC=1)(=O)=O>CCOCC>[CH3:20][O:21][CH2:22][CH2:23][CH2:24][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([OH:12])=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1

参加物

4

反応物 2

HCID 135229883-Methoxypropyl 4-methylbenzenesulfonateHCID 19348616Methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate

生成物 1

HCID 193487163-[4-(3-Methoxypropoxy)-2-methoxyphenyl]heptanoic Acid

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Following a similar procedure to that described in Preparation 45A(i), but using methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate (prepared as described in Preparation 58A), and 3-methoxy-1-tosyloxypropane, the corresponding ether derivative was obtained. Hydrolysis of this derivative and subsequent treatment of the reaction mixture were conducted in a similar manner to that described in Preparation 7 to give the title compound as an oily substance.

後処理

  1. customthat described in Preparation 45A(i)
  2. customHydrolysis of this derivative and subsequent treatment of the reaction mixture
  3. customdescribed in Preparation 7

出典と根拠

ORDレコード
ord-6675ecc54324439a8c127f99f53fcf69
出典データセット
uspto-grants-1999_03
特許番号
US05880147

反応ノート

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