Hydrochloric Acid → HCID 67610940、化合物

反応式

C1O[C:4]2([CH2:9][CH2:8][N:7]([C:10]([N:12]3[CH:16]=[CH:15][N:14]=[CH:13]3)=[O:11])[CH2:6][CH2:5]2)OC1.[ClH:18].Cl.[NH2:20][C:21]1[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:22]=1[C:23]([NH2:25])=[NH:24].Cl>C(O)C>[ClH:18].[NH2:25][C:23]1[C:22]2[C:21](=[CH:29][CH:28]=[CH:27][C:26]=2[F:30])[NH:20][C:4]2([CH2:5][CH2:6][N:7]([C:10]([N:12]3[CH:16]=[CH:15][N:14]=[CH:13]3)=[O:11])[CH2:8][CH2:9]2)[N:24]=1

参加物

反応条件

温度: 55 °C

実験手順

1-(1H-Imidazol-1-ylcarbonyl)-4-piperidone ethylene ketal (Example EE, 156 mg., 0.66 mmol) was added to 2-amino-6-fluorobenzamidine dihydrochloride (150 mg, 0.66 is mmol) in ethanol (10 ml) together with an excess of HCl (1M in ether). This mixture was heated to 55° C. overnight, concentrated in vacuo and purified by flash column chromatography eluting with dichloromethane, increasing the gradient to dichloromethane/methanol (10:1), to give a solid which triturated from ethanol/ether to give yellow crystals, m.p. 260° C. (dec.).