4,6-Dimethoxy-2-(2-nitrobenzyl)pyrimidine → 2-(4,6-Dimethoxypyrimidin-2-ylmethyl)aniline
反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-])=O)[N:4]=1>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])[N:4]=1参加物
3
実験手順
The product of stage (i) (32.6 g) was added to a stirred suspension of stannous chloride dihydrate (133 g) in ethanol (300 ml). After refluxing for 2 hours the solution was poured into ice-water (2500 ml) and extracted with ethyl acetate (3×500 ml). The combined extracts were washed with saturated sodium chloride solution, dried and evaporated to give 24.3 g of the desired product as a brown solid, mp 82°-84° C.
後処理
- temperatureAfter refluxing for 2 hours the solution
- extractionextracted with ethyl acetate (3×500 ml)
- washThe combined extracts were washed with saturated sodium chloride solution
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-62fcfcf1b9be4a16af79779a9ec63feb
- 出典データセット
- uspto-grants-1999_03
- 特許番号
- US05885935
反応ノート
読み込み中…