Hydrochloric Acid → 4-Methoxy-N-methyl-2-nitrobenzenamine

HRID 1419120

反応式

HRID 1419120 の反応式
C(O[C:6]([N:8](C)[C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18])=O)(C)(C)C.Cl>O1CCOCC1>[CH3:6][NH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 53900404tert-butyl N-(4-methoxy-2-nitrophenyl)-N-methylcarbamate

生成物 1

HCID 35543134-Methoxy-N-methyl-2-nitrobenzenamine収率 90.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A procedure similar to that described in Preparation 8 was repeated, except that 2.0 g of N-t-butoxycarbonyl-N-methyl-4-methoxy-2-nitroaniline (prepared as described in Preparation 23) and 30 ml of a 4N solution of hydrogen chloride in 1,4-dioxane were used, to give 1.17 g of the title compound having an Rf value=0.62 (on thin layer chromatography on silica gel; developing solvent: a 1:5 by volume mixture of ethyl acetate and hexane).

後処理

  1. customA procedure similar to that described in Preparation 8

出典と根拠

ORDレコード
ord-d6fe830b6cb54433860642699266d1f2
出典データセット
uspto-grants-1999_03
特許番号
US05886014

関連ノート

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