5-Cyano-1-[3-(N-t-butoxycarbonyl-1,2,5,6-tetrahydropyrid-4-yl)indol-5-yl]-1H-benzimidazole → 5-Cyano-1-[3-(1,2,5,6-tetrahydropyrid-4-yl)indol-5-yl]-1H-benzimidazole
反応式
[C:1]([C:3]1[CH:33]=[CH:32][C:6]2[N:7]([C:10]3[CH:11]=[C:12]4[C:16](=[CH:17][CH:18]=3)[NH:15][CH:14]=[C:13]4[C:19]3[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH:20]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1)#[N:2]>C(Cl)Cl>[C:1]([C:3]1[CH:33]=[CH:32][C:6]2[N:7]([C:10]3[CH:11]=[C:12]4[C:16](=[CH:17][CH:18]=3)[NH:15][CH:14]=[C:13]4[C:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH:20]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1)#[N:2]参加物
3
実験手順
5-Cyano-1-[3-(N-t-butoxycarbonyl-1,2,5,6-tetrahydropyrid-4-yl)indol-5-yl]-1H-benzimidazole was used, and methylene chloride was used as solvent. Filtration afforded the title compound (75%) as a yellow solid: mp, decomposes at 240° C.; IR (KBr) 2228 cm-1 ; 13C NMR (CD3OD) δ 144.4, 137.9, 133.6, 131.1, 129.9, 126.0, 125.3, 125.2, 120.1, 118.4, 118.3, 117.5, 117.3, 116.1, 114.8, 113.2, 112.9, 110.4, 66.7, 42.0, 40.9. Anal. calcd. for C21H17N5.1.1 C4H8O2 [dioxane].1.1 HCl: C, 64.03; H, 5.69; N, 14.70. Found: C, 64.20; H, 5.54; N, 14.47.