Ammonia → 6-Cyano-1-(2-carbamoylvinyl)-2-naphthol

HRID 1419255ノート

反応式

HRID 1419255 の反応式
[NH3:1].[C:2]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]([CH:14]=[CH:15][C:16](OCC)=[O:17])=[C:9]([OH:21])[CH:8]=[CH:7]2)#[N:3]>>[C:2]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]([CH:14]=[CH:15][C:16](=[O:17])[NH2:1])=[C:9]([OH:21])[CH:8]=[CH:7]2)#[N:3]

参加物

3

反応物 2

HCID 222AmmoniaHCID 53697716HCID 53697716、化合物

生成物 1

HCID 537790446-Cyano-1-(2-carbamoylvinyl)-2-naphthol

実験手順

2.0 Liters of 25% aqueous ammonia was added to 25.2 g of 6-cyano-1-(2-ethoxycarbonylvinyl)-2-naphthol, followed by stirring at 40°-45° C. for 32 hours. After cooling, the reaction mixture was concentrated to 300 ml under reduced pressure, and the residue was stirred for 30 minutes under cooling with water. The precipitate was collected by filtration and washed with a small amount of water and acetone to obtain 9.55 g of the desired product.

後処理

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture was concentrated to 300 ml under reduced pressure
  3. stirringthe residue was stirred for 30 minutes
  4. temperatureunder cooling with water
  5. filtrationThe precipitate was collected by filtration
  6. washwashed with a small amount of water and acetone

出典と根拠

ORDレコード
ord-18b1e4c054544813a05ae764760e7d6d
出典データセット
uspto-grants-1999_03
特許番号
US05885990

反応ノート

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