4,5-Dihydro-2-(methylthio)thiazole → 1-(4,5-Dihydrothiazol-2-yl)azetidin-3-ol
反応式
Cl.[OH:2][CH:3]1[CH2:6][NH:5][CH2:4]1.CS[C:9]1[S:10][CH2:11][CH2:12][N:13]=1.C[O-].[Na+]>C(O)C>[OH:2][CH:3]1[CH2:6][N:5]([C:9]2[S:10][CH2:11][CH2:12][N:13]=2)[CH2:4]1参加物
5
実験手順
To a solution of 109 mg of 3-hydroxyazetidine HCl [Compound (15)] in 5 ml of ethanol was added a mixture of 133 mg of 2-methylthiothiazoline [Compound (16)] and sodium methoxide (0.9 equivalent mole), and the reaction mixture was refluxed for 8 hours. After removal of the solvent under reduced pressure, the resulting residue was dissolved in chloroform and washed with saturated saline solution. After removal of the solvent under reduced pressure, the resulting residue was washed with diethylether to give 119 mg (81.5%) of 3-hydroxy-1-(thiazolin-2-yl)azetidine [Compound (17)] as crystals.
後処理
- temperaturethe reaction mixture was refluxed for 8 hours
- customAfter removal of the solvent under reduced pressure
- dissolutionthe resulting residue was dissolved in chloroform
- washwashed with saturated saline solution
- customAfter removal of the solvent under reduced pressure
- washthe resulting residue was washed with diethylether
出典と根拠
- ORDレコード
- ord-4ac4a670b0e74c919204719ffebfd63a
- 出典データセット
- uspto-grants-1999_03
- 特許番号
- US05886172
反応ノート
読み込み中…