Carbon Dioxide → HCID 178516780、化合物

HRID 1419483ノート

反応式

HRID 1419483 の反応式
NC[C:3]([C:5]1[N:6]=[CH:7][N:8]([C@@H:15]2[O:20][C@H:19]([CH2:21][OH:22])[C@@H:17]([OH:18])[C@H:16]2[F:23])[C:9]=1[N:10]=[CH:11][N:12](C)[CH3:13])=[O:4].C[O-].[Na+].C(=O)=O>CO>[F:23][C@@H:16]1[C@H:17]([OH:18])[C@@H:19]([CH2:21][OH:22])[O:20][C@H:15]1[N:8]1[C:9]2[N:10]=[CH:11][NH:12][CH2:13][C:3](=[O:4])[C:5]=2[N:6]=[CH:7]1

参加物

5

反応物 3

HCID 280Carbon DioxideHCID 10942334Sodium MethoxideHCID 537945224-aminoacetyl-1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-5-(dimethylaminomethyleneamino)imidazole

生成物 1

HCID 178516780HCID 178516780、化合物収率 36%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

The compound (24) (20 mg) obtained in item (13) above was dissolved in methanol (0.4 ml), to which was added a 0.2M sodium methylate solution (0.4 ml) in methanol and the resulting mixture was allowed to stand at room temperature overnight. The reaction solution obtained was neutralized with addition of dry ice, then concentrated to leave a residue and the residue was purified by silica gel column chromatography (developer; chloroform-methanol, 4:1), affording the titled compound (25) (6.2 mg) as a colorless solid. Yield: 36%.

後処理

  1. customThe reaction solution obtained
  2. concentrationconcentrated
  3. customto leave a residue
  4. customthe residue was purified by silica gel column chromatography (developer; chloroform-methanol, 4:1)

出典と根拠

ORDレコード
ord-9d6120a78bae44259dfc44240380669a
出典データセット
uspto-grants-1999_03
特許番号
US05886167

反応ノート

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