Potassium Carbonate → HCID 178448114、化合物

HRID 1419800ノート

反応式

HRID 1419800 の反応式
Cl[C:2]1[C:7]([Cl:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1.[C:11]([CH:14]1[CH2:19][CH2:18][CH:17]([NH2:20])[CH2:16][CH2:15]1)([CH3:13])=[CH2:12].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Cl:8][C:7]1[C:2]([NH:20][C@H:17]2[CH2:18][CH2:19][C@@H:14]([C:11]([CH3:13])=[CH2:12])[CH2:15][CH2:16]2)=[N:3][CH:4]=[N:5][C:6]=1[CH2:9][CH3:10]

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 111376684,5-Dichloro-6-ethylpyrimidineHCID 540303434-Isopropenylcyclohexylamine

生成物 1

HCID 178448114HCID 178448114、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

1.6 g (0.009 mol) of 4,5-dichloro-6-ethylpyrimidine and 1.2 g (0.009 mol) of 4-isopropenylcyclohexylamine were stirred with 1.8 g (0.013 mol) of K2CO3 in 10 ml of DMF at 80° C. for 6 hours. After cooling to room temperature, the mixture was placed in water and extracted with ether. The organic phase was washed with water, dried and filtered, and the filtrate was chromatographed on silica gel with petroleum ether/ethyl acetate 7:3 in order to separate the cis/trans isomers.

後処理

  1. extractionextracted with ether
  2. washThe organic phase was washed with water
  3. customdried
  4. filtrationfiltered
  5. customthe filtrate was chromatographed on silica gel with petroleum ether/ethyl acetate 7:3 in order
  6. customto separate the cis/trans isomers

出典と根拠

ORDレコード
ord-c05b3b2636594daea4524067c447dec8
出典データセット
uspto-grants-1999_03
特許番号
US05889012

反応ノート

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