Water → (4-Methylpyridin-2-yl)acetonitrile

HRID 1419854ノート

反応式

HRID 1419854 の反応式
Cl[CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1.[C-:10]#[N:11].[K+].O>CS(C)=O>[C:10]([CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1)#[N:11]

参加物

5

反応物 3

HCID 962WaterHCID 9032Potassium CyanideHCID 126752612-(Chloromethyl)-4-methylpyridine

生成物 1

HCID 12812206(4-Methylpyridin-2-yl)acetonitrile収率 1,112.3%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

2-chloromethyl-4-methylpyridine (3.70 g, 2.17 mmol) was dissolved in dimethyl sulfoxide (9 ml) and herein potassium cyanide (1.70 g, 2.60 mmol) was added. After stirring for 17 hours at room temperature, water was added and it was extracted twice with diethyl ether. The combined organic layers were dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to get crude product. The residue was separated and purified by column-chromatography over silica gel to obtain the desired product (3.19 g, yield=95%).

後処理

  1. extractionit was extracted twice with diethyl ether
  2. dry with materialThe combined organic layers were dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customto get crude product
  5. customThe residue was separated
  6. custompurified by column-chromatography over silica gel

出典と根拠

ORDレコード
ord-7cb8e14c17ad495b86580b80c13e8021
出典データセット
uspto-grants-1999_03
特許番号
US05889027

反応ノート

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