関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Amino-4-methylpyridine | HCID 1533 | — |
| 反応物 | 2-(Chlorothio)-benzoyl chloride | HCID 10910715 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2-(4-Methylpyridin-2-yl)-3-oxo-3h-benzo[d]isothiazole | HCID 15871327 | 37.1% |
反応手順
Using the method of Fischer and Hurni (Arzneimittel Forsch., 1964;14:1301) 5.4 g (0.05 mol) of 2-amino-4-methylpyridine in 50 mL of pyridine at 10° C. was reacted with 10.3 g (0.05 mol) of 2-chlorosulfenylbenzoyl chloride. The mixture was heated to 50° C. and maintained at that temperature for 2 hours. The mixture was cooled to 25° C. and filtered. The solid was recrystallized from benzene to give 4.5 g of the title compound, mp 195°-196.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05889034 |
|---|
| 出典データセット | uspto-grants-1999_03 |
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| ORD ID | ord-ef5ee94c30244c50bb1409a88010faa5 |
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| 出典メモ | uspto-grants-1999_03 |
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