Potassium Carbonate → 9-Phenylnonan-2-one

HRID 1420527ノート

反応式

HRID 1420527 の反応式
I[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[C:14]([CH2:17]C(=O)C)(=[O:16])[CH3:15].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[C:8]1([CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:15][C:14](=[O:16])[CH3:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 31261AcetylacetoneHCID 145296726-Phenyl-1-hexyl iodide

生成物 1

HCID 187819999-Phenylnonan-2-one収率 54%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

6-Iodo-1-phenylhexane (17.43 g, 0.061 mol), acetyl acetone(6.66 g, 0.067) and potassium carbonate (8.41 g, 0.061 mol) were dissolved in dry absolute ethanol (75 ml) nd the solution was retluxed for 18 hours. After cooling to room temperature the solution was filtered and evaporated under reduced pressure to an oil. This was partitioned between ethyl acetate (80 ml) and water (80 ml), and the organic layer was washed with brine, dried and evaporated to an orange oil (15.27 g). This was purified by flash chromatography on silica gel using petroleum ether/ethyl acetate to give 9-phenylnonan-2-one as a colourless oil (7.12 g, 54%).

後処理

  1. filtrationwas filtered
  2. customevaporated under reduced pressure to an oil
  3. customThis was partitioned between ethyl acetate (80 ml) and water (80 ml)
  4. washthe organic layer was washed with brine
  5. customdried
  6. customevaporated to an orange oil (15.27 g)
  7. customThis was purified by flash chromatography on silica gel

出典と根拠

ORDレコード
ord-80084a365440440e94850acbfdf238ce
出典データセット
uspto-grants-2000_06
特許番号
US06071899

反応ノート

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