4-Bromophenol → p-Bromophenyl propionate

HRID 1420751

反応式

HRID 1420751 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:16](Cl)(=[O:19])[CH2:17][CH3:18]>CN(C)C1C=CN=CC=1.ClCCl>[C:16]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:19])[CH2:17][CH3:18]

参加物

6

反応物 3

HCID 78084-BromophenolHCID 8471TriethylamineHCID 62324Propionyl chloride

生成物 1

HCID 90205p-Bromophenyl propionate

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

4-Bromophenol (259 g) and 4-dimethylaminopyridine (1.5 g) were dissolved in dichloromethane (1000 ml), the solution was cooled in an ice bath and triethylamine (219 ml) was added portionwise such that the reaction temperature was kept below 20° C. Propionyl chloride (137 ml) was then added over 1 hour and the resulting mixture was stirred at room temperature for 2 hours. The mixture was washed with water followed by brine, then dried (anhydrous magnesium sulphate) and the solvent removed under reduced pressure to yield 4-bromophenyl propionate (344 g) as a green oil.

後処理

  1. temperaturethe solution was cooled in an ice bath
  2. customwas kept below 20° C
  3. washThe mixture was washed with water
  4. dry with materialdried (anhydrous magnesium sulphate)
  5. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-da8fdcec4c6a4e39998f08b7090c8fe6
出典データセット
uspto-grants-2000_06
特許番号
US06071938

関連ノート

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