4-Bromoanisole → 1-(5-Bromo-2-hydroxyphenyl)propan-1-one

HRID 1420767

反応式

HRID 1420767 の反応式
[Cl-].[Cl-].[Cl-].[Al+3].[C:5](Cl)(=[O:8])[CH2:6][CH3:7].[Br:10][C:11]1[CH:16]=[CH:15][C:14]([O:17]C)=[CH:13][CH:12]=1>ClCCl>[Br:10][C:11]1[CH:7]=[CH:6][C:5]([OH:8])=[C:13]([C:14](=[O:17])[CH2:15][CH3:16])[CH:12]=1

参加物

5

反応物 3

HCID 77304-BromoanisoleHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 7364091-(5-Bromo-2-hydroxyphenyl)propan-1-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a stirred mixture of aluminium trichloride (2.5 kg) in dichloromethane (5000 ml) at room temperature was added propanoyl chloride (864 g) over a 5 minute period. The mixture was stirred for 45 minutes at room temperature and then a solution of 4-bromoanisole (875 g) in dichloromethane (1000 ml) was added over 15 minutes. The reaction was heated under reflux for 6 hours then cooled and stirred at room temperature overnight.

後処理

  1. temperatureThe reaction was heated
  2. temperatureunder reflux for 6 hours
  3. temperaturethen cooled
  4. stirringstirred at room temperature overnight

出典と根拠

ORDレコード
ord-e19719302dfe4818a83baf43fda5d170
出典データセット
uspto-grants-2000_06
特許番号
US06071938

関連ノート

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