4-Chloropyridinium chloride → HCID 11243907、化合物

HRID 1420769ノート

反応式

HRID 1420769 の反応式
CO[C:3]1(OC)[CH2:7][CH2:6][CH2:5]O1.[Cl-].ClC1C=C[NH+]=CC=1.[NH2:18][C:19]1[C:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[O:30][CH3:31])=[CH:22][S:21][C:20]=1[C:32]([O:34][CH3:35])=[O:33]>O1CCOCC1>[CH3:31][O:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[C:23]1[C:19]([N:18]2[CH:3]=[CH:7][CH:6]=[CH:5]2)=[C:20]([C:32]([O:34][CH3:35])=[O:33])[S:21][CH:22]=1

参加物

5

反応物 3

HCID 108772904-Chloropyridinium chlorideHCID 11311579HCID 11311579、化合物HCID 11788317Dimethoxytetrahydrofurane

生成物 1

HCID 11243907HCID 11243907、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

5.2 mmol of dimethoxytetrahydrofuran and 5.2 mmol of 4-chloropyridinium chloride in 100 ml of dioxane are stirred for 15 minutes at ambient temperature and then 5.2 mmol of the compound obtained in Step C are added. The reaction mixture is then heated at reflux of the solvent for 3 hours and subsequently filtered. After concentrating the filtrate under reduced pressure, the residue obtained is crystallised by trituration in ethyl ether, allowing the expected product to be isolated.

後処理

  1. temperatureThe reaction mixture is then heated
  2. temperatureat reflux of the solvent for 3 hours
  3. filtrationsubsequently filtered
  4. concentrationAfter concentrating the filtrate under reduced pressure
  5. customthe residue obtained
  6. customis crystallised by trituration in ethyl ether
  7. customto be isolated

出典と根拠

ORDレコード
ord-26cb5e0cfa7247b680d4ed77986e50ee
出典データセット
uspto-grants-2000_06
特許番号
US06071945

反応ノート

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