Ethylenediamine → HCID 18783142、化合物

HRID 1420868ノート

反応式

HRID 1420868 の反応式
[CH3:1][C:2]1([CH3:11])[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4](=O)[CH2:3]1.C(N)CN.[N+:16]([CH3:19])([O-:18])=[O:17]>>[N+:16]([CH2:19][C:4]1[CH2:3][C:2]([CH3:11])([CH3:1])[CH2:7][C:6]([CH3:9])([CH3:8])[CH:5]=1)([O-:18])=[O:17]

参加物

4

反応物 3

HCID 3301EthylenediamineHCID 6375NitromethaneHCID 843993,3,5,5-Tetramethylcyclohexanone

生成物 1

HCID 18783142HCID 18783142、化合物収率 61%

実験手順

A solution of 3,3,5,5-tetramethylcyclohexanone (2-13) (1.54 g, 10 mmol) and ethylenediamine (60 mg) in nitromethane (45 ml) was refluxed in argon atmosphere for 25 h. Excess of nitromethane was then removed in vacuo and the residue was purified by flash chromatography on silica gel, eluting with hexane-ethyl acetate (6:1). 1.2 g (61%) of 6 was obtained as an oil.

後処理

  1. customExcess of nitromethane was then removed in vacuo
  2. customthe residue was purified by flash chromatography on silica gel
  3. washeluting with hexane-ethyl acetate (6:1)

出典と根拠

ORDレコード
ord-b4bb1bc1af6944428d818ec8bee00cd8
出典データセット
uspto-grants-2000_06
特許番号
US06071966

反応ノート

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