Water → (2-Methoxypyridin-4-yl)methanol
反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9](OCC)=[O:10])[CH:6]=[CH:5][N:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>CCOCC>[OH:10][CH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=1参加物
5
反応条件
- 温度
- 5 °C
実験手順
A solution of ethyl 2-methoxy-pyridine-4-carboxylate (0.93 g, 5 mmol) in ether (5 ml) was added to lithium aluminium hydride (0.3 g, 8 mmol) in ether (10 ml) cooled to 5° C. and the mixture stirred for 2 hours. Water was added, the mixture was filtered through diatomaceous earth and the pad was washed through with ethyl acetate. The filtrate was extracted with ethyl acetate and the combined extracts were washed with brine, dried (MgSO4) and the solvent removed by evaporation to give 4-hydroxymethyl-2-methoxypyridine (0.64 g, 89%) as a yellow oil.
後処理
- filtrationthe mixture was filtered through diatomaceous earth
- washthe pad was washed through with ethyl acetate
- extractionThe filtrate was extracted with ethyl acetate
- washthe combined extracts were washed with brine
- dry with materialdried (MgSO4)
- customthe solvent removed by evaporation
出典と根拠
- ORDレコード
- ord-4538502dba81421fa9a0d59f43296204
- 出典データセット
- uspto-grants-2000_06
- 特許番号
- US06071921
反応ノート
読み込み中…