化工社化工社 化学情報印刷レポート · 研究参考用
Avermectin → Ivermectin CRS
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Avermectin | HCID 6858006 | — |
| 反応物 | Tris-(octylphenyl)-phosphine | HCID 22561076 | — |
| 生成物 | Ivermectin CRS | HCID 9812710 | — |
反応手順
4.3 g of avermectin (B1a and B1b mixture) are, after addition of 53.2 mg of tris-(octylphenyl)-phosphine, hydrogenated using the conditions given in Example 1 (B). After a hydrogenation time of 7 hours, a crude ivermectin product is obtained which, according to HPLC analysis, contains 1.3% of avermectin, 94.8% of ivermectin and 2% of tetrahydroavermectin.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06072052 |
| 出典データセット | uspto-grants-2000_06 |
| ORD ID | ord-ec79b6c038e94f30b0a3c8bf2cfedba0 |
| 出典メモ | uspto-grants-2000_06 |