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Ammonium Chloride → 5-(Hydroxymethyl)furan-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | Methyl 5-cyanofuran-2-carboxylate | HCID 13011707 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-(Hydroxymethyl)furan-2-carbonitrile | HCID 3021406 | — |
反応手順
A solution of the ester from step 1 (0.098 g, 0.652 mmol), in ethanol (2.5 ml) at 0° C. was treated with sodium borohydride (0.11 g, 2.936 mmol) and the reaction was stirred for 2 hrs. Saturated NH4Cl solution (1 ml) was added and the aqueous extracted with diethylether. The combined extracts were dried (MgSO4) and evaporated in vacuo. The residue was chromatographed (silica gel, diethylether) to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06077853 |
| 出典データセット | uspto-grants-2000_06 |
| ORD ID | ord-0f69dbcd0e5247d9b9ae3edacd9a6513 |
| 出典メモ | uspto-grants-2000_06 |