Imidazole → 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

HRID 1421725ノート

反応式

HRID 1421725 の反応式
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([OH:11])[CH:4]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>CN(C=O)C>[OH:11][C:5]1[CH:4]=[C:3]([CH2:2][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:10]=[CH:9][C:6]=1[C:7]#[N:8]

参加物

4

反応物 2

HCID 795ImidazoleHCID 216969934-(Bromomethyl)-2-hydroxybenzonitrile

生成物 1

HCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-Bromomethyl-2-hydroxybenzonitrile (0.222 g, 1.045 mmol) and imidazole (0.356 g, 5.23 mmol) were stirred in DMF (10 mL) at ambient temperature for 18 hr. The reaction mixture was concentrated in vacuo to remove the DMF, and the residue was chromatographed (SiO2, 2-5% CH3OH in CH2Cl2) to give the title compound.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto remove the DMF
  3. customthe residue was chromatographed (SiO2, 2-5% CH3OH in CH2Cl2)

出典と根拠

ORDレコード
ord-570b20861e5e454a9d7a4d8f0351e9aa
出典データセット
uspto-grants-2000_06
特許番号
US06077853

反応ノート

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