Ethanol → HCID 385223、化合物

HRID 1421871ノート

反応式

HRID 1421871 の反応式
OC[CH:3]([NH2:8])[CH:4]1[CH2:7][CH2:6][CH2:5]1.[NH2:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[C:12]([Cl:17])[N:11]=1.[CH2:18]([OH:20])C>C(N(CC)CC)C>[NH2:9][C:10]1[N:15]=[C:14]([NH:8][CH2:3][C:4]2([CH2:18][OH:20])[CH2:5][CH2:6][CH2:7]2)[CH:13]=[C:12]([Cl:17])[N:11]=1

参加物

5

反応物 3

HCID 702EthanolHCID 655222-Amino-4,6-dichloropyrimidineHCID 15458387HCID 15458387、化合物

生成物 1

HCID 385223HCID 385223、化合物収率 92.3%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

A mixture of 1-hydroxymethyl-1-cyclobutylmethylamine (5.75 g, 0.05 mol), 2-amino-4,6-dichloropyrimidine (8.20 g, 0.05 mol), ethanol (200 ml) and triethylamine (20 ml) was refluxed for one day. The solvent was distilled away under reduced pressure. The residue was washed with water, dried and recrystallized from acetone to give colorless prism crystals (11.2 g, 92.3%), m.p. 192-194° C. (acetone).

後処理

  1. temperaturewas refluxed for one day
  2. distillationThe solvent was distilled away under reduced pressure
  3. washThe residue was washed with water
  4. customdried
  5. customrecrystallized from acetone

出典と根拠

ORDレコード
ord-2da758854a624c0887b4f377db1896d1
出典データセット
uspto-grants-2000_06
特許番号
US06080750

反応ノート

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