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1,3-Dichloroacetone → 4-(Chloromethyl)-2-(3,4-dimethoxyphenyl)-1,3-thiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Dichloroacetone | HCID 10793 | — |
| 反応物 | 3,4-Dimethoxythiobenzamide | HCID 2758490 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(Chloromethyl)-2-(3,4-dimethoxyphenyl)-1,3-thiazole | HCID 2079396 | 59.1% |
反応手順
1.5 g of 1,3-dichloroacetone and 2.3 g of 3,4-dimethoxythiobenzamide were suspended in 100 ml of ethanol. The suspension was heated for 3 hours to complete the reaction. The solvent was removed by distillation. The residue was purified by silica gel column chromatography to obtain 1.86 g of 2-(3,4-dimethoxyphenyl)-4-chloromethylthiazole as a colorless viscous oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06080764 |
| 出典データセット | uspto-grants-2000_06 |
| ORD ID | ord-5498671472d94442b51712a9af07884e |
| 出典メモ | uspto-grants-2000_06 |