Hydrochloric Acid → 4-Fluorobenzimidic acid ethyl ester hydrochloride

HRID 1422056ノート

反応式

HRID 1422056 の反応式
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[ClH:10].[CH2:11]([OH:13])[CH3:12]>>[ClH:10].[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:13][CH2:11][CH3:12])=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 145174-Fluorobenzonitrile

生成物 1

HCID 122821594-Fluorobenzimidic acid ethyl ester hydrochloride収率 92%

実験手順

Into a solution of 4-fluorobenznitrile (50.9 g, 0.420 mol) in ethanol (500 mL) was blown hydrogen chloride to saturation under ice-cooling and the mixture was stirred at room temperature for 21 hours. The solvent was evaporated under reduced pressure and the obtained crystals were washed with ether and dried in vacuo to give ethyl 4-fluorobenzimidate hydrochloride as white crystals (78.8 g, 92%).

後処理

  1. temperaturecooling
  2. customThe solvent was evaporated under reduced pressure
  3. washthe obtained crystals were washed with ether
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-21e48446e8d948debcdc37e22b76d4f5
出典データセット
uspto-grants-2000_06
特許番号
US06080738

反応ノート

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