Water → HCID 53927376、化合物

HRID 1422221ノート

反応式

HRID 1422221 の反応式
C([O:3][C:4](=[O:24])[CH:5]=[CH:6][C:7](=[O:23])[NH:8][CH2:9][C:10]1[CH:19]=[C:18]([Br:20])[CH:17]=[C:16]2[C:11]=1[NH:12][C:13](=[O:22])[C:14](=[O:21])[NH:15]2)C.O.[OH-].[Li+].O>O1CCCC1.O>[Br:20][C:18]1[CH:17]=[C:16]2[C:11]([NH:12][C:13](=[O:22])[C:14](=[O:21])[NH:15]2)=[C:10]([CH2:9][NH:8][C:7]([CH:6]=[CH:5][C:4]([OH:24])=[O:3])=[O:23])[CH:19]=1

参加物

5

反応物 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 54239092HCID 54239092、化合物

生成物 1

HCID 53927376HCID 53927376、化合物

試薬・触媒・溶媒 1

HCID 21881883Oxolane--water (1/1)溶媒

実験手順

144 mg (0.36 mmol) of 3-[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-carbamoyl]-acrylic acid ethyl ester (Example 10) and 76 mg of lithium hydroxide hydrate are dissolved in 18 ml of tetrahydrofuran/water (2:1) and the solution is stirred for 18 hours. 50 ml of water are added, the tetrahydrofuran is concentrated by evaporation and the solution is acidified with 1 N hydrochloric acid. The solid is filtered off, washed with water and dried.

後処理

  1. concentrationthe tetrahydrofuran is concentrated by evaporation
  2. filtrationThe solid is filtered off
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-e0eb2b2da8ec42e688511afacfd80e93
出典データセット
uspto-grants-2000_06
特許番号
US06080743

反応ノート

読み込み中…