Acetic Anhydride → N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-acetamide

HRID 1422231ノート

反応式

HRID 1422231 の反応式
Cl.[NH2:2][CH2:3][C:4]1[CH:13]=[C:12]([Br:14])[CH:11]=[C:10]2[C:5]=1[NH:6][C:7](=[O:16])[C:8](=[O:15])[NH:9]2.[C:17](OC(=O)C)(=[O:19])[CH3:18].C(N(CC)CC)C>CN(C)C=O>[Br:14][C:12]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:16])[C:8](=[O:15])[NH:9]2)=[C:4]([CH2:3][NH:2][C:17](=[O:19])[CH3:18])[CH:13]=1

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 18706500HCID 18706500、化合物

生成物 1

HCID 18706505N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-acetamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

50 mg (0.19 mmol) of 5-aminomethyl-7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline hydrochloride are suspended in 4 ml of N,N-dimethylformamide and stirred at 20° C. for 24 hours with 0.02 ml (1.2 equiv.) of acetic anhydride and 0.059 ml (2.2 equiv.) of triethylamine. The solvent is concentrated by evaporation, and the solid is suspended in diethyl ether, filtered off and washed with methanol and diethyl ether. After drying under a high vacuum, the title compound is obtained in the form of a white solid.

後処理

  1. concentrationThe solvent is concentrated by evaporation
  2. filtrationfiltered off
  3. washwashed with methanol and diethyl ether
  4. customAfter drying under a high vacuum

出典と根拠

ORDレコード
ord-22f4f01f53a6475285274e50acbb0726
出典データセット
uspto-grants-2000_06
特許番号
US06080743

反応ノート

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