Carbon tetrabromide → HCID 53770216、化合物

HRID 1422344ノート

反応式

HRID 1422344 の反応式
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:20]([Br:24])(Br)(Br)Br.[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:40]=[CH:39][C:36](CO)=[CH:35][CH:34]=2)[CH:29]=[C:30]([Cl:32])[CH:31]=1>C(OCC)C.C(Cl)Cl>[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:40]=[CH:39][C:36]([CH2:20][Br:24])=[CH:35][CH:34]=2)[CH:29]=[C:30]([Cl:32])[CH:31]=1

参加物

6

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 11288229(3',5'-Dichloro[1,1'-biphenyl]-4-yl)methanol

生成物 1

HCID 53770216HCID 53770216、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of triphenylphospine (636 mg, 2.42 mmol) and carbon tetrabromide (830 mg, 2.50 mmol) in diethyl ether (5 mL) was added a solution of 4-(3',5'-bis-chlorophenyl) benzyl alcohol (50 mg, 1.98 mmol) in CH2Cl2 (12 mL). The reaction was stirred at ambient temperature for 16 hours, silica gel was than added and the solvent evaporated in vacuo. The product was isolated by chromatography (Silica gel, 10-30% EtOAc in hexanes) and obtained as a white solid.

後処理

  1. additionthan added
  2. customthe solvent evaporated in vacuo
  3. customThe product was isolated by chromatography (Silica gel, 10-30% EtOAc in hexanes)
  4. customobtained as a white solid

出典と根拠

ORDレコード
ord-bad8f4f388c7478aa18d0c8d52b766e7
出典データセット
uspto-grants-2000_06
特許番号
US06080870

反応ノート

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