Water → 8-Bromo-3-(4-fluorophenyl)-imidazo[1,5-a]pyridine
反応式
[Br:1][C:2]1[C:3]([CH2:8][NH:9][C:10](=O)[C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.O.C(=O)([O-])[O-].[K+].[K+]>O=P(Cl)(Cl)Cl>[Br:1][C:2]1[C:3]2[N:4]([C:10]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)=[N:9][CH:8]=2)[CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
A mixture of N-(3-bromopyridin-2-ylmethyl)-4-fluoro-benzamide (594 mg, 1.92 mmol) in POCl3 (5.0 mL) is warmed at reflux. After 1.5 hours, the mixture is cooled to room temperature and poured into water while adding crushed ice to control the exotherm. The mixture is made basic with potassium carbonate and the precipitate is collected by filtration to afford 8-bromo-3-(4-fluorophenyl)-imidazo[1,5-a]pyridine.
後処理
- temperatureis warmed
- temperatureat reflux
- additionwhile adding
- customcrushed ice
- filtrationthe precipitate is collected by filtration
出典と根拠
- ORDレコード
- ord-8eca7b9c1663474aa8ed7425d631c30f
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08927550B2
反応ノート
読み込み中…